![]() ![]() Hope changed his name to Bob when classmates ridiculed his English schoolboy name. A highly competitive golfer, he later shot in the 70s and sponsored the Bob Hope Golf Classic, one of the nation's biggest tournaments. He also worked as a caddy and developed a lifelong fondness for golf. The boy helped out by selling newspapers and working in a shoe store, a drug store and a meat market. They found themselves in the backwash of the 1907 depression. The Hopes emigrated to the United States when he was 4 and settled in Cleveland. He was born Leslie Townes Hope on May 29, 1903, in Eltham, England, the fifth of seven sons of a British stonemason and a Welsh singer of light opera. ``He can't believe that this is happening and that he's made it to his Big 100,'' son Kelly Hope said at the time. The fabled intersection of Hollywood Boulevard and Vine Street was renamed Bob Hope Square, and President Bush established the Bob Hope American Patriot Award. ![]() On his 100th birthday, he was too frail to take part in public celebrations, but was said to be alert and happy - and overwhelmed by the outpouring of affection. ![]() He never let a good joke die - if it got a laugh in Vietnam, it would get a laugh in Saudi Arabia. Hope had a reputation as an ad-libber, but he kept a stable of writers and had filing cabinets full of jokes. So often was Hope away entertaining, and so little did he see his wife, Dolores, and their four adopted children, that he once remarked, ``When I get home these days, my kids think I've been booked on a personal appearance tour.'' He headlined in so many war zones that he had a standard joke for the times he was interrupted by gunfire: ``I wonder which one of my pictures they saw?'' Through he said he was afraid of flying, Hope traveled countless miles to entertain servicemen in field hospitals, jungles and aircraft carriers from France to Berlin to Vietnam to the Persian Gulf. Hope earned a fortune, gave lavishly to charity and was showered with awards, so many that he had to rent a warehouse to store them. Woody Allen called Hope ``the most influential comedian for me.'' He was admired by his peers, and generations of younger comedians. ``You never tire of talking with your best friends.'' ``Audiences are my best friends,'' he liked to say. No matter that the joke was old or flat he was Bob Hope and he got laughs. When Hope went into one of his monologues, it was almost as though the world was conditioned to respond. ![]()
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![]() Durable and super portable, you will get much use out of this convenient haccessory. The NexImage Burst Color is made out of machined aluminum with a 1.25" adapter barrel with C-threads for direct threaded connection to almost any telescope. The best part is the ability to manually adjust gain, exposure time, frame rate and color balance so you have full control over the NexImage Burst. You also won't need to invest in filters and a filter wheel. There's no need to image the same target multiple times to capture different colors. NexImage Burst Color is a one-shot color camera, allowing you to capture full-color images instantly. ![]() You won’t find the Aptina AR0132 sensor for a better price anywhere than NexImage Burst. This updated version of the popular MT9M034 sensor offers the perfect combination of speed, sensitivity, and value. 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Haemangiomas can grow rapidly, but most of the time they are harmless. This has to be done in pharmaceutical-grade laboratories, and can be difficult and take a lot of time. This could be used to treat haemangiomas and maybe other vascular abnormalities and cancers. What does that mean for patients? We’d like to see this research translated and propranolol reformulated into a drug that is just the ( R)-(+) enantiomer. 132, e156863 2022), which are needed to create the tumour. Instead, it inhibits haemangioma’s stem cells from forming blood vessels ( S. We found that one of these compounds, ( R)-(+)-propranolol, isn’t a β-blocker, so it doesn’t block the effects of adrenaline and reduce blood pressure. It turns out that the drug is made up of two enantiomers - mirror-image molecular compounds. A lot of the work we’ve done involves determining how known cancer drugs function, which we hope can help us to come up with new ones.įor example, in 2008, a group in France discovered, kind of by accident, that propranolol, a β-blocker that’s used to treat high blood pressure and various heart conditions, works well on haemangiomas ( C. Now, my laboratory is doing basic science on tumour cells, but of course we want this science to be translated to the clinic. I thought, wow, you have all the mechanisms of angiogenesis here and maybe if we can learn how this vessel growth and then regression is occurring in haemangiomas, then that knowledge about a regression of blood vessels that supply tumours can be applied to other diseases. ![]() I picked haemangioma - a red mark on the skin that is made up of multiplying blood vessels and one of the most common birthmarks - because this is a tumour that grows dramatically in the first five to six months of a baby’s life and then, in most cases, begins to shrink by the child’s first birthday. It was fantastic because I was exposed to not just research on tumour angiogenesis - the proliferation of a network of blood vessels that supply oxygen and nutrients to a tumour - but also to work on infantile haemangioma. In 1990, an opportunity arose to join Boston Children’s Hospital as a principal investigator and Harvard Medical School in Boston, Massachusetts, as an assistant professor. Towards the end of my postdoc, which was at the Whitehead Institute in Cambridge, Massachusetts, I remember thinking that I really wanted to feel like my research was having an impact on disease. ![]() Username .My PhD and postdoctoral fellowship were in basic science - the mechanisms of cells and how proteins get to where they need to go. To take an assessment using an ACCESS CODE. Illuminate Education offers SSO through Clever Instant Login . How Illuminate Education works with Clever. Illuminate Education - Clever application gallery | Clever Welcome to the Illuminate Home Connection Portal! Learn all about how to navigate the portal as a student here. Thanks! To take a test using an ACCESS CODE given to you by your teacher click here to go to illuminate.online. Copyright © 2022 Illuminate Education, Inc. Welcome to Illuminate Education! Illuminate Education. If this isn't your district, you can search for your district here. 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Even smaller still, defeated enemies will sometimes crawl helplessly on the ground desperately trying to escape you, you can wipe the blood off your sword, you can bow to pay respect to your opponent, and the list goes on and on. The on-screen HUD is minimalist and the camera always stays really tight so you can get an up-close view of the action enemies have clear audio tells so that even if you can’t see them you know when to dodge or block fatal attacks often end with Jin spinning around to face the camera while your enemy stumbles around with blood spurting out before finally keeling over. The little touches go a long way toward combat’s exquisite feel, in addition to bringing a bit of visual spectacle. Later on you’ll learn the Water Stance, which uses slower but more powerful strikes that can break through the defenses of shield-wielding enemies. The starting Stone Stance is ideal for dealing with swordsmen, as one charged-up stab attack can sneak through their guard and either kill them outright or deal massive damage. As Jin completes certain tasks, he’ll unlock new sword stances that each come with their own movesets, and, more importantly, their own strengths versus a particular type of weapon. That probably all sounds familiar, but the glue that holds this combat system together and allows it to remain interesting the whole way through is the addition of the stances you can shift between at the push of a button. Like all great combat systems, it’s simple to understand on a surface level: there are light attacks to quickly deal damage and beat out slower strikes, heavy attacks that deal more damage and can break through enemy guards, a block button to guard against certain attacks, and a dodge button to avoid the attacks that can’t be guarded. And, as witches’ brews tend to be, the result is magical. 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